La Dépêche, formally La Dépêche du Midi, is a regional daily newspaper published in Toulouse in south-west France with 17 editions for different areas of the Midi-Pyrénées region. The main local editions are for: Toulouse, Ariège, Aude, Aveyron, Haute-Garonne, Gers, Lot, Lot-et-Garonne, Hautes-Pyrénées, Tarn, and Tarn-et-Garonne.

The newspaper first appeared on 2 October 1870 when it was called La Dépêche de Toulouse. Publication was prompted by workers at the Sirven print works in Toulouse, which established the paper's left-leaning politics. It was at La Dépêche that the socialist politician Jean Jaurès wrote his first articles. The paper also published the articles by Georges Clémenceau. In the big issue of the day, the Dreyfus affair, the paper first insisted Alfred Dreyfus had given army secrets to the Germans but then came out in his support.